Measurement of tricyclic antidepressants. Part II. Applications of methodology.

Measurement of tricyclic antidepressants. Part I. A review of methodology.

Introduction Various methods for the measurement of tricyclic antidepressant drugs have been described since 1960. An outline of the chemical structure of the tricyclics and related drugs is shown in Figure 1. Common to the majority of methods is the need for extraction of the drug from the biological medium before analysis. This usually involves extraction of an alkaline medium with an organic...

tricyclic antidepressants: old drugs-new applications

Tricyclic Antidepressants: Old Drugs-New Applications

With great interest I have read an excellent article " Evaluation of the efficacy of intrathecal injection of amitripty-line and doxepin in spinal anesthesia in comparison with bupivacaine in rats " , published in your respected journal. The authors present and elaborate a very interesting subject of the application of tricyclic antidepressants as a local anesthetic. I totally agree with the au...

Tricyclic antidepressants.

Tricyclic antidepressants.

Correspondence BRiTISH 301 Tricyclic Antidepressants SIR,-I am worried by one sentence in the article on tricyclic antidepressants (13 April, p. 102): "Jaundice, which is very uncommon , is of the cholestatic type similar to that found in chlorpromazine." This is misleading. Jaundice is one of the more frequent side-effects reported from imipramine and imitrip-tyline, the most widely used membe...